반응 #1672698

ord-a608778e069a4b2a8e53d95cfd135f92

반응 방정식

C[C@H]1CO[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](O)CC[C@]6(C)[C@H]5[C@@H](O)[C@H](OC(=O)C(Cl)(Cl)Cl)[C@]4(C)[C@H]3[C@@H]2C)C(Br)C1
(3β,5α, 11β,12α,25R)-23-bromo-12-(trichloroacetoxy)-spirostan-3,11-diol
→
C[C@@H]1CC[C@@]2(OC1)O[C@H]1C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4[C@@H](O)[C@H](O)[C@]3(C)[C@H]1[C@@H]2C
title compound
C[C@@H]1CC[C@@]2(OC1)O[C@H]1C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4[C@@H](O)[C@H](O)[C@]3(C)[C@H]1[C@@H]2C
(3β,5α, 11β,12α,25R)-spirostan-3,11,12-triol

반응물

C[C@H]1CO[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](O)CC[C@]6(C)[C@H]5[C@@H](O)[C@H](OC(=O)C(Cl)(Cl)Cl)[C@]4(C)[C@H]3[C@@H]2C)C(Br)C1
(3β,5α, 11β,12α,25R)-23-bromo-12-(trichloroacetoxy)-spirostan-3,11-diol

시약

[Zn]
zinc

용매

CC(=O)O
acetic acid

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Using the procedure described in J. Chem. Soc., 1956, 4330, (3β,5α, 11β,12α,25R)-23-bromo-12-(trichloroacetoxy)-spirostan-3,11-diol was reduced with zinc and acetic acid to give the title compound.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05939398uspto-grants-1999_08