반응 #167259

반응 방정식

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

6-bromo-quinoline

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

수율 43.7%

1-(4-Methyl-pyridin-3-yl)-3-quinolin-6-yl-imidazolidin-2-one

수율 43.7%

용매

1,4-dioxane

반응 조건

후처리

1. 1
   기타to afford the crude product
2. 2
   기타Purification by column chromatography on silica gel (0.5% MeOH in CHCl3)

실험 절차

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 200 mg, 1.13 mmol) was reacted with 6-bromo-quinoline (233.9 mg, 1.13 mmol), 1,4-dioxane (15 mL), copper iodide (16.53 mg, 0.113 mmol), trans-1,2-diamino cyclohexane (0.04 mL, 0.339 mmol) and potassium carbonate (312 mg, 2.26 mmol) to afford the crude product. Purification by column chromatography on silica gel (0.5% MeOH in CHCl3) afforded 150 mg of the product (43.668% yield).

출처