반응 #167245

반응 방정식

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

4-bromo-benzonitrile

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

수율 64.2%

4-[3-(4-Methyl-pyridin-3-yl)-2-oxo-imidazolidin-1-yl]-benzonitrile

수율 64.2%

용매

1,4-dioxane

반응 조건

후처리

1. 1
   기타to afford the crude product
2. 2
   기타Purification by column chromatography on silica gel (5% MeOH in DCM)

실험 절차

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.8465 mmol) was reacted with 4-bromo-benzonitrile (154 mg, 0.84650 mmol), 1,4-dioxane (50 mL), copper iodide (16 mg, 0.084650 mmol), trans-1,2-diamino cyclohexane (29 mg, 0.2539 mmol) and potassium carbonate (468 mg, 3.3860 mmol) to afford the crude product. Purification by column chromatography on silica gel (5% MeOH in DCM) afforded 151 mg of the product (64.2% yield).

출처