반응 #167239

반응 방정식

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

5-bromo-2-chloro-pyrimidine

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

수율 26.5%

1-(2-Chloro-pyrimidin-5-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

수율 26.5%

용매

1,4-dioxane

반응 조건

후처리

1. 1
   기타to afford the crude product
2. 2
   기타Purification by column chromatography on silica gel (2% MeOH in chloroform)

실험 절차

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.8465 mmol) was reacted with 5-bromo-2-chloro-pyrimidine (163.7 mg, 0.8465 mmol), 1,4-dioxane (30 mL), copper iodide (16 mg, 0.08465 mmol), trans-1,2-diamino cyclohexane (29 mg, 0.2539 mmol) and potassium carbonate (468 mg, 3.3860 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in chloroform), followed by preparative HPLC afforded 65 mg of the product (26.5% yield).

출처