반응 #167236

반응 방정식

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

3-bromo-thiophene

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

수율 10.0%

1-(4-Methyl-pyridin-3-yl)-3-thiophen-3-yl-imidazolidin-2-one

수율 10.0%

용매

1,4-dioxane

반응 조건

후처리

1. 1
   기타to afford the crude product
2. 2
   기타Purification by column chromatography on silica gel (2% MeOH in chloroform)

실험 절차

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.8474 mmol) was reacted with 3-bromo-thiophene (79.4 mL, 0.8474 mmol), 1,4-dioxane (10 mL), copper iodide (16.13 mg, 0.084 mmol), trans-1,2-diamino cyclohexane (30.5 mL, 0.254 mmol) and potassium carbonate (234 mg, 1.695 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in chloroform), followed by preparative HPLC afforded 22 mg of the product (10% yield).

출처