반응 #167231

반응 방정식

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

2-bromo-benzo[b]thiophene

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

수율 62.5%

1-Benzo[b]thiophen-2-yl-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

수율 62.5%

용매

1,4-dioxane

반응 조건

후처리

1. 1
   기타to afford the crude product
2. 2
   기타Purification by column chromatography on silica gel (1% MeOH in chloroform)

실험 절차

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 109.25 mg, 0.6171 mmol) was reacted with 2-bromo-benzo[b]thiophene (150 mg, 0.6171 mmol), 1,4-dioxane (5 mL), copper iodide (11.75 mg, 0.06171 mmol), trans-1,2-diamino cyclohexane (21.19 mg, 0.1851 mmol) and potassium carbonate (170.62 mg, 1.2342 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in chloroform) afforded 75 mg of the product (62.5% yield).

출처