반응 #167215

반응 방정식

1-pyridin-3-yl-tetrahydro-pyrimidin-2-one

2-bromo-naphthalene

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

수율 35.7%

1-Naphthalen-2-yl-3-pyridin-3-yl-tetrahydro-pyrimidin-2-one

수율 35.7%

용매

1,4-dioxane

반응 조건

후처리

1. 1
   기타to afford the crude product
2. 2
   기타Purification by column chromatography on silica gel (1% MeOH in chloroform)

실험 절차

Using the same reaction conditions as in Example 1, 1-pyridin-3-yl-tetrahydro-pyrimidin-2-one (I-10b: 118 mg, 0.724 mmol) was reacted with 2-bromo-naphthalene (150 mg, 0.724 mmol), 1,4-dioxane (5 mL), copper iodide (13.79 mg, 0.0724 mmol), trans-1,2-diamino cyclohexane (24.865 mg, 0.2172 mmol) and potassium carbonate (200 mg, 1.448 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in chloroform) afforded 75 mg of the product (35.71% yield).

출처