반응 #167065

반응 방정식

HCl

Methyl chloroformate

2-Amino-3-cyano-propionic acid

NaOH

→

3-Cyano-2-methoxycarbonylamino-propionic acid

수율 20.0%

용매

THF

반응 조건

후처리

1. 1
   추출the aqueous phase was extracted 3× with diethyl ether
2. 2
   건조The combined organics were dried over MgSO4
3. 3
   여과filtered
4. 4
   농축concentrated

실험 절차

Methyl chloroformate (0.81 mL, 10.51 mmol) was added dropwise to a stirred suspension of 2-Amino-3-cyano-propionic acid (1.00 g, 8.76 mmol) and NaOH (5 N in H2O, 4.2 mL, 21.0 mmol) in THF (20 mL). After stirring at room temperature for 7 h, the reaction mixture was poured into 10% HCl and the aqueous phase was extracted 3× with diethyl ether. The combined organics were dried over MgSO4, filtered and concentrated to afford 3-Cyano-2-methoxycarbonylamino-propionic acid (295 mg, 20%).

출처