반응 #1670489

반응 방정식

n-octanol

pyridine

alpha-chloroethyl chloroformate

→

title product

수율 69.4%

alpha-Chloroethyl Octyl Carbonate

수율 69.4%

용매

ether

반응 조건

후처리

1. 1
   기타prepared
2. 2
   여과then filtered
3. 3
   농축The filtrate was concentrated in vacuo
4. 4
   workup.DISTILLATIONdistilled at 102°-107° C. (2 mm)

실험 절차

To a stirring solution of dry n-octanol (6.42 g, 49.3 mmol) and pyridine (3.90 g, 49.3 mmol) in anhydrous ether (75 mL) was added at 0° C. alpha-chloroethyl chloroformate (prepared according to U.K. Pat. No. 1,426,717; 7.00 g, 49.3 mmol). The mixture was stirred vigorously for three hours at 25° C. then filtered. The filtrate was concentrated in vacuo and distilled at 102°-107° C. (2 mm) affording 8.1 g title product as a clear oil (34.2 mmol, 69.4%): 1H NMR (CDCl3) delta 0.44-2.03 (m, 15H), 1.60 (d, J=6 Hz, 3H), 3.94 (t, J=7 Hz, 2H), 6.18 (q, J=6 Hz, 1H).

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