반응 #167035

반응 방정식

4,4′-dibromo-2-methoxy-2′-nitro-biphenyl

hydrazine

→

4,4′-dibromo-2′-methoxy-biphenyl-2-ylamine

수율 100.0%

용매

ethanol

ethanol

반응 조건

후처리

1. 1
   온도The mixture was refluxed for 7 hours
2. 2
   여과filtered through a pad of CELITE
3. 3
   세척The CELITE pad was washed with ethanol
4. 4
   농축The combined solution was concentrated under reduced pressure

실험 절차

To a suspension of 4,4′-dibromo-2-methoxy-2′-nitro-biphenyl (3.76 g, 9.8 mmol) and 5% Ru/C (400 mg) in ethanol (37 ml) at 65-70° C. was added dropwise a solution of hydrazine (4.6 ml, 59 mmol) in ethanol (5 ml). The mixture was refluxed for 7 hours and filtered through a pad of CELITE. The CELITE pad was washed with ethanol. The combined solution was concentrated under reduced pressure. Coevaporation with ethanol, EtOAc and DCM gave 4,4′-dibromo-2′-methoxy-biphenyl-2-ylamine as yellow solid (3.5 g).

출처