반응 #1666396

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1-tert.-butyl-5-chloro-3-phenyl-2,1-benzisoxazolium tetrafluoroborate

morpholine

→

1-tert.-butyl-5-chloro-3-morpholino-3-phenyl-2,1-benzisoxazoline

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후처리

1. 1
   workup.ADDITIONTo a flask containing 6 g
2. 2
   세척The reaction mixture is washed in diethyl ether
3. 3
   기타water and the ether layer separated
4. 4
   기타dried
5. 5
   기타evaporated in vacuo to dryness
6. 6
   기타the residue recrystallized from ether

실험 절차

To a flask containing 6 g. of 1-tert.-butyl-5-chloro-3-phenyl-2,1-benzisoxazolium tetrafluoroborate is added 9 ml. of morpholine and the mixture heated at 80°C. with stirring for 1 hour. The reaction mixture is washed in diethyl ether and water and the ether layer separated, dried, evaporated in vacuo to dryness and the residue recrystallized from ether to obtain 1-tert.-butyl-5-chloro-3-morpholino-3-phenyl-2,1-benzisoxazoline, m.p. 130°-132°C.

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