반응 #166411

반응 방정식

compound 399

9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

→

compound 400

수율 138.9%

1-oxa-4,9-diazaspiro[5.5]undecan-3-one

수율 138.9%

용매

ethanol

반응 조건

후처리

1. 1
   건조palladium hydroxide, 20 wt % pd (dry basis) on carbon, wet (300 mg, 427 μmol)
2. 2
   기타for 6 days
3. 3
   여과the mixture was filtered
4. 4
   농축concentrated in vacuo

실험 절차

To a solution of compound 399 (316.1 mg, 1214 μmol) in ethanol (15 mL) was added palladium hydroxide, 20 wt % pd (dry basis) on carbon, wet (300 mg, 427 μmol). After hydrogenating the reaction mixture at 50 psi for 6 days, the mixture was filtered thru a plug of celite and concentrated in vacuo to give compound 400 (287.0 mg). LCMS-ESI (POS), M/Z, M+1: Found 171.1, Calculated 171.1.

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