반응 #1664054

반응 방정식

hydrochloric acid

methyl 3-[(tetrahydropyran-2-yl)oxy]-bicyclo[3.1.0]hexane-6-carboxylate

Methyl 3-[(tetrahydropyran-2-yl)oxy]bicyclo[3.1.0]-hexane-6-carboxylate

sodium hydroxide

→

3-[(Tetrahydropyran-2-yl)oxy]bicyclo[3.1.0]hexane-6-carboxylic acid

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONA mixture of 5 g
2. 2
   온도Cooling
3. 3
   기타evaporation of the ethanol
4. 4
   workup.ADDITIONunder reduced pressure, and addition of 100 ml
5. 5
   기타of water gives a solution which
6. 6
   추출extracted with diethyl ether
7. 7
   추출The diethyl ether extract
8. 8
   건조is dried with anhydrous sodium sulfate
9. 9
   기타evaporated
10. 10
    기타to give

실험 절차

A mixture of 5 g. of methyl 3-[(tetrahydropyran-2-yl)oxy]-bicyclo[3.1.0]hexane-6-carboxylate (VIII, syn and anti, from Example 3), ethanol (45 ml.), and sodium hydroxide (10 ml. of a 20% aqueous solution) is refluxed for 20 minutes. Cooling evaporation of the ethanol under reduced pressure, and addition of 100 ml. of water gives a solution which is acidified with dilute hydrochloric acid and extracted with diethyl ether. The diethyl ether extract is dried with anhydrous sodium sulfate and evaporated to give a mixture of exo syn and anti 3-[(tetrahydropyran-2-yl)oxy]bicyclo[3.1.0]hexane-6-carboxylic acid.

출처