반응 #166209

반응 방정식

4-fluoro-2-(2-fluoro-4-methylsulfanyl-phenylamino)-3-formyl-benzoic acid

hydrazine hydrate

→

title compound

수율 82.0%

4-(2-Fluoro-4-methylsulfanyl-phenylamino)-1H-indazole-5-carboxylic acid

수율 82.0%

용매

DME

반응 조건

후처리

1. 1
   기타The volatile solvent was removed in vacuo
2. 2
   온도whilst applying cooling
3. 3
   여과The resultant precipitate was collected by filtration
4. 4
   세척washed with water

실험 절차

To a suspension of 4-fluoro-2-(2-fluoro-4-methylsulfanyl-phenylamino)-3-formyl-benzoic acid (105 mg, 0.32 mmol) in DME (5 mL) was added hydrazine hydrate (5 mL) and the reaction mixture heated at 90° C. for 18 hours. The volatile solvent was removed in vacuo and the residue acidified with concentrated HCl whilst applying cooling. The resultant precipitate was collected by filtration and washed with water to give the title compound as a tan solid (85 mg, 82%). LCMS (Method B) RT 3.12 [M+H]+ 318.

출처