반응 #166187

반응 방정식

4-cyclopropyl-2-fluoro-1-nitro-benzene

→

title compound

4-Cyclopropyl-2-fluoro-phenylamine

용매

반응 조건

후처리

1. 1
   기타the atmosphere was evacuated
2. 2
   workup.ADDITIONback-filled with nitrogen
3. 3
   기타then re-evacuated
4. 4
   workup.ADDITIONback-filled with hydrogen
5. 5
   여과before filtering through a pad of Celite®
6. 6
   세척then washing with ethyl acetate
7. 7
   농축The filtrate was concentrated in vacuo

실험 절차

A slurry of palladium on carbon (200 mg, 10% wt.) in IMS was added to a degassed solution of 4-cyclopropyl-2-fluoro-1-nitro-benzene (1.45 g, 8 mmol) in IMS (50 mL), the atmosphere was evacuated and back-filled with nitrogen then re-evacuated and back-filled with hydrogen. The reaction mixture was stirred under 1 atmosphere pressure of hydrogen at room temperature for 24 hours before filtering through a pad of Celite® then washing with ethyl acetate. The filtrate was concentrated in vacuo to give the title compound as a pale purple residue (1.19 g, 98%). 1H NMR (CDCl3, 400 MHz) 6.72-6.63 (3 H, m), 3.56 (2 H, s), 1.83-1.75 (1 H, m), 0.93-0.82 (2 H, m), 0.59-0.54 (2 H, m).

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