반응 #166085

반응 방정식

NaCNBH3

Trans-5-amino-2-diphenylmethyl-tetrahydropyran

Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine

4-nitrobenzaldehyde

acetic acid

→

compound 16d

수율 80.0%

Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(4-nitro-benzyl)-amine

수율 80.0%

용매

methanol

1,2-dichloroethane

반응 조건

실험 절차

Trans-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.1 g, 0.38 mmol) was reacted with 4-nitrobenzaldehyde (0.057 g, 0.38 mmol) in the presence of glacial acetic acid (0.023 g, 0.38 mmol) in 1,2-dichloroethane (20 ml), and then reduced by NaCNBH3 (0.03 g, 0.45 mmol) in methanol (5 ml) (Procedure D) to give compound 16d (0.12 g, 80%) as an oil.

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