반응 #165946
ord-07434e418da045c8b635ed127911d12c
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상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타the volatiles were removed in vacuo
- 2기타The crude material was purified by preparative reversed phase HPLC
실험 절차
3-[(4-iodo-2-methylphenyl)amino]isonicotinic acid 2c (60 mg, 0.17 mmol) was dissolved in 6 ml dry DMF followed by the addition of DIPEA (0.20 mmol, 37 μl), ByBOP (0.20 mmol, 107 mg) and O-ethylhydroxylamine hydrochloride (0.34 mmol, 34 mg). The mixture was stirred for 4 h and the volatiles were removed in vacuo. The crude material was purified by preparative reversed phase HPLC to give 36 mg (91 μmol; 53% yield) of pure desired product.