반응 #165834

ord-69524c100c5247dc8905c65244ff7dc6

반응 방정식

CC(C)S(=O)(=O)c1ccc(-c2cnc(N)c(C(=O)NN)n2)cc1
3-amino-6-(4-isopropylsulfonylphenyl)pyrazine-2-carbohydrazide
CC(=O)N=C=S
acetyl isothiocyanate
→
CC(=O)NC(=S)NNC(=O)c1nc(-c2ccc(S(=O)(=O)C(C)C)cc2)cnc1N
N-(2-(3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazine-2-carbonyl) hydrazinecarbonothioyl)ethanamide

반응물

CC(C)S(=O)(=O)c1ccc(-c2cnc(N)c(C(=O)NN)n2)cc1
3-amino-6-(4-isopropylsulfonylphenyl)pyrazine-2-carbohydrazide
CC(=O)N=C=S
acetyl isothiocyanate

시약

없음

용매

ClCCCl
DCE

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    농축concentrated in vacuo
  2. 2
    기타Used directly in the next step without further purification

실험 절차

A mixture of 3-amino-6-(4-isopropylsulfonylphenyl)pyrazine-2-carbohydrazide (100 mg, 0.2982 mmol), acetyl isothiocyanate (30.16 mg, 26.20 μL, 0.2982 mmol) and dry DCE (2.000 mL) were stirred at ambient temperature for 2 h and then concentrated in vacuo. Used directly in the next step without further purification; MS (ES+) 437.20

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08841308B2uspto-grants-2014_09