반응 #165803

반응 방정식

(benzotriazol-1-yloxy-dimethylamino-methylene)-dimethyl-ammonium tetrafluoroborate

4-[5-amino-6-(hydrazinecarbonyl)pyrazin-2-yl]-N,N-dimethyl-benzamide

6-aminopyridine-2-carboxylic acid

triethylamine

→

4-(5-amino-6-(2-(6-aminopyridine-2-carbonyl)hydrazinecarbonyl)pyrazin-2-yl)-N,N-dimethylbenzamide

용매

DMF

반응 조건

후처리

1. 1
   온도then warmed slightly
2. 2
   workup.ADDITIONThe mixture was poured dropwise onto water (5 ml) with rapid stirring
3. 3
   workup.STIRRINGstirred at room temperature for 1 h
4. 4
   여과then filtered
5. 5
   기타to give a wet paste which
6. 6
   기타was dried under high vacuum at 100° C. overnight
7. 7
   기타Used directly in the next step without purification

실험 절차

A solution of 4-[5-amino-6-(hydrazinecarbonyl)pyrazin-2-yl]-N,N-dimethyl-benzamide (100 mg, 0.3163 mmol) and 6-aminopyridine-2-carboxylic acid (43.69 mg, 0.3163 mmol) in DMF (1.000 mL) was treated with triethylamine (32.01 mg, 44.09 μL, 0.3163 mmol) then warmed slightly. The mixture was cooled to room temperature and then treated with (benzotriazol-1-yloxy-dimethylamino-methylene)-dimethyl-ammonium tetrafluoroborate (121.9 mg, 0.3796 mmol) and stirred at room temperature overnight. The mixture was poured dropwise onto water (5 ml) with rapid stirring, stirred at room temperature for 1 h then filtered to give a wet paste which was dried under high vacuum at 100° C. overnight. Used directly in the next step without purification.

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