반응 #165779

반응 방정식

NaHCO3

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

→

5-bromo-3-(5-phenyl-1,2,4-oxadiazol-3-yl)pyrazin-2-amine

수율 76.0%

용매

water

반응 조건

후처리

1. 1
   온도to cool to RT
2. 2
   기타The resulting precipitate was isolated by filtration
3. 3
   기타dried (643 mg, 76% Yield)

실험 절차

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide (890 mg, 2.648 mmol) and polyphosphonic acid (3.560 mL) were mixed and the reaction heated to 70° C. Further polyphosphonic acid (8.900 mL) was added and the reaction allowed to stir for a further 3 hours at 70° C. The mixture was then allowed to cool to RT, diluted with water and neutralised by the portionwise addition of solid NaHCO3. The resulting precipitate was isolated by filtration and dried (643 mg, 76% Yield). 1H NMR (400.0 MHz, DMSO) d 7.49 (2H, br s), 7.69 (2H, m), 7.77 (1H, m), 8.28 (2H, m), 8.43 (1H, s); MS (ES+) 319.89

출처