반응 #165751

반응 방정식

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide

triethylamine

benzoyl chloride

→

product

수율 70.0%

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

수율 70.0%

용매

DCM

반응 조건

후처리

1. 1
   workup.ADDITIONwere added
2. 2
   기타the solvent was removed in vacuo
3. 3
   기타the residue triturated with MeOH
4. 4
   여과The resultant filtrate was filtered off

실험 절차

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide (770 mg, 3.318 mmol) was suspended in DCM (10 mL) and triethylamine (369.3 mg, 508.7 μL, 3.650 mmol) followed by benzoyl chloride (513.1 mg, 423.7 μL, 3.650 mmol) were added. After 1 hour, the solvent was removed in vacuo and the residue triturated with MeOH. The resultant filtrate was filtered off to furnish the product as an off-white solid (779 mg, 70% Yield).

출처