반응 #165704

반응 방정식

mixture

N-(5-acetyl-4-methylthiazol-2-yl)-5-chloro-2-methoxybenzamide

1-bromobutane

potassium t-butoxide

→

title compound

(Z)—N-(5-acetyl-3-butyl-4-methylthiazol-2(3H)-ylidene)-5-chloro-2-methoxybenzamide

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   기타quenched with 5 mL of saturated aquesous NH4Cl
2. 2
   workup.ADDITIONdiluted with 5 mL of ethyl acetate
3. 3
   기타The layers were separated
4. 4
   추출the aqueous phase was extracted twice with 5 mL of ethyl acetate
5. 5
   건조The combined organic extracts were dried over anhydrous Na2SO4
6. 6
   여과filtered
7. 7
   농축concentrated under reduced pressure
8. 8
   기타Purification via column chromatography (SiO2, 40% hexanes in ethyl acetate)

실험 절차

A mixture of Example 238A (0.40 g, 1.2 mmol), 1-bromobutane (0.16 mL, 1.5 mmol), and potassium t-butoxide (0.22 g, 1.9 mmol) in 5 mL N,N-dimethylformamide was warmed to 65° C. and stirred for 20 hours. The mixture was cooled to ambient temperature quenched with 5 mL of saturated aquesous NH4Cl and diluted with 5 mL of ethyl acetate. The layers were separated and the aqueous phase was extracted twice with 5 mL of ethyl acetate. The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Purification via column chromatography (SiO2, 40% hexanes in ethyl acetate) afforded the title compound. 1H NMR (300 MHz, CD3OD) δ ppm 1.04 (t, J=7.3 Hz, 3H), 1.42-1.55 (m, 2H), 1.77-1.90 (m, 2H), 2.51 (s, 3H), 2.76 (s, 3H), 3.88 (s, 3H), 4.32-4.41 (m, 2H), 7.10 (d, J=8.8 Hz, 1H), 7.45 (dd, J=8.8, 2.7 Hz, 1H), 7.99 (d, J=3.1 Hz, 1H); MS (DCI/NH3) m/z 381 (M+H)+. Anal. Calculated for C18H21ClN2O3S: C, 56.76; H, 5.56; N, 7.35. Found: C, 56.68; H, 5.49; N, 7.26.

출처