반응 #165586

반응 방정식

5-fluoro-2-methylbenzoic acid

thionyl chloride

→

title compound

5-Fluoro-2-methyl-benzoyl chloride

반응 조건

후처리

1. 1
   온도to reflux for 3 hours
2. 2
   기타the volatile components were removed under reduced pressure
3. 3
   workup.DISSOLUTIONThe residue was dissolved in fresh toluene (10 mL)
4. 4
   농축concentrated under reduced pressure twice

실험 절차

A solution of 5-fluoro-2-methylbenzoic acid (380 mg, 2.47 mmol) in thionyl chloride (5 mL) was heated to reflux for 3 hours. The solution was cooled to ambient temperature and the volatile components were removed under reduced pressure. The residue was dissolved in fresh toluene (10 mL) and concentrated under reduced pressure twice and then placed under high vacuum to afford the title compound (420 mg).

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