반응 #165377

반응 방정식

6-methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine

methanol

potassium carbonate

→

title compound

수율 88.0%

5-Ethynyl-6-methyl-pyridin-2-ylamine

수율 88.0%

용매

Water

반응 조건

후처리

1. 1
   추출was extracted with ethyl acetate
2. 2
   세척The organic layer was washed with saturated aqueous sodium chloride
3. 3
   농축was concentrated under a reduced pressure
4. 4
   기타The residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:1)

실험 절차

To a mixture of 6-methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine (450 mg, 1.9 mmol) described in Manufacturing Example 187-1-1 and methanol (5 mL) was added potassium carbonate (390 mg, 2.8 mmol), which was stirred for 30 minutes at the same temperature. Water was added to the reaction mixture, which was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, and was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:1) to obtain the title compound (220 mg, 88%).

출처