반응 #165340

반응 방정식

sodium hydroxide

5-[1,3]dioxolan-2-yl-2-(pyridin-2-yloxymethyl)-pyridine

dimethyl sulfoxide

hydrochloric acid

→

title compound

수율 48.1%

6-(Pyridin-2-yloxymethyl)-pyridine-3-carbaldehyde

수율 48.1%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.WAITfor another 1 hour at 20 minutes at 60° C
2. 2
   추출which was extracted with ethyl acetate
3. 3
   기타The organic layer was separated
4. 4
   세척washed with saturated aqueous sodium chloride
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   여과filtered
7. 7
   농축The filtrate was concentrated under a reduced pressure
8. 8
   기타the residue was purified by silica gel column chromatography (heptane: ethyl acetate=1:1)

실험 절차

To a solution of 5-[1,3]dioxolan-2-yl-2-(pyridin-2-yloxymethyl)-pyridine (1.51 g, 5.85 mmol) described in Manufacturing Example 154-1-5 in tetrahydrofuran (15 mL) and dimethyl sulfoxide (10 mL) was added a 5 N hydrochloric acid aqueous solution (3 mL), which was stirred for 25 minutes at room temperature, and then for another 1 hour at 20 minutes at 60° C. A 5 N sodium hydroxide aqueous solution was added to the reaction mixture at room temperature, which was extracted with ethyl acetate. The organic layer was separated, washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure, and the residue was purified by silica gel column chromatography (heptane: ethyl acetate=1:1) to obtain the title compound (603 mg, 48%).

출처