반응 #165042

반응 방정식

(4-(pyridin-2-yloxymethyl)-phenyl)methanol

triphenylphosphine

carbon tetrachloride

→

title compound

수율 51.1%

2-(4-Chloromethyl-benzyloxy)-pyridine

수율 51.1%

반응 조건

후처리

1. 1
   온도under reflux for 2 hours and 10 minutes
2. 2
   농축concentrated under a reduced pressure
3. 3
   기타The residue was purified by silica gel column chromatography (heptane: acetic acid=8:1)

실험 절차

A mixture of (4-(pyridin-2-yloxymethyl)-phenyl)methanol (540 mg, 2.51 mmol) described in Manufacturing Example 2-1-1, triphenylphosphine (856 mg, 3.27 mmol) and carbon tetrachloride (10.8 g, 10.2 mmol) was stirred under reflux for 2 hours and 10 minutes. The reaction solution was cooled to room temperature, and concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane: acetic acid=8:1) to obtain the title compound (300 mg, 51.1%).

출처