반응 #164977

반응 방정식

3-iodopyridin-2-ylamine

N,N-diisopropylethylamine

N-methylpyrrolidinone

trimethylsilylacetylene

→

title compound

수율 80.7%

3-Trimethylsilanylethynyl-pyridin-2-ylamine

수율 80.7%

용매

Water

반응 조건

후처리

1. 1
   추출was then extracted with ethyl acetate 4 times
2. 2
   농축The solvent was concentrated under a reduced pressure
3. 3
   기타The residue was purified by NH silica gel chromatography (heptane:ethyl acetate=4:1)
4. 4
   농축The resulting solution was concentrated under a reduced pressure
5. 5
   기타the residue was purified by silica gel chromatography (heptane

실험 절차

To a mixture of 3-iodopyridin-2-ylamine (40.2 g, 183 mmol) described in Manufacturing Example 1-2-1, trimethylsilylacetylene (51.7 mL, 366 mmol), copper (I) iodide (3.49 g, 18.3 mmol), N,N-diisopropylethylamine (63.7 mL, 366 mmol) and N-methylpyrrolidinone (200 mL) was added tetrakis(triphenylphosphine)palladium (0) (10.6 g, 9.15 mmol) under nitrogen atmosphere, which was stirred for 3 hours and 10 minutes at room temperature. Water was added to the reaction solution, which was then extracted with ethyl acetate 4 times. The solvent was concentrated under a reduced pressure. The residue was purified by NH silica gel chromatography (heptane:ethyl acetate=4:1). The resulting solution was concentrated under a reduced pressure, and the residue was purified by silica gel chromatography (heptane:ethyl acetate=2:1 then 1:1) to obtain the title compound (28.1 g, 80.7%).

출처