반응 #164945

반응 방정식

2-Fluoro-5-iodo-3-nitro-benzoic acid

SOCl2

MeOH

→

2-fluoro-5-iodo-3-nitro-benzoic acid methyl ester

수율 96.0%

반응 조건

후처리

1. 1
   온도the mixture was refluxed for two hours
2. 2
   기타Solvent was evaporated under reduced pressure
3. 3
   workup.DISSOLUTIONthe residue was dissolved in EtOAa
4. 4
   세척The EtOAc slolution was washed with brine
5. 5
   기타dried over NasSO4
6. 6
   여과filtered
7. 7
   농축concentrated under reduced pressure

실험 절차

2-Fluoro-5-iodo-3-nitro-benzoic acid (2.0 g, 6.43 mmol) and SOCl2 (918 mg, 7.72 mmol) were added to 20 mL MeOH, and the mixture was refluxed for two hours and then cooled to room temperature. Solvent was evaporated under reduced pressure and the residue was dissolved in EtOAa. The EtOAc slolution was washed with brine, dried over NasSO4, filtered and concentrated under reduced pressure to give 2.0 g (96%) of 2-fluoro-5-iodo-3-nitro-benzoic acid methyl ester.

출처