반응 #164940

반응 방정식

2-tert-Butoxycarbonylamino-propionic acid

HOBt

NMP

EDCI

thiomorpholine

→

(1-Methyl-2-oxo-2-thiomorpholin-4-yl-ethyl)-carbamic acid tert-butyl ester

수율 98.5%

용매

CH2Cl2

반응 조건

후처리

1. 1
   세척washed with 2% aqueous NaOH, water, brine
2. 2
   건조dried over Na2SO4
3. 3
   기타The solvent was removed under vacuum

실험 절차

To a solution of 2-tert-Butoxycarbonylamino-propionic acid (3.5 g, 18.5 mmol), HOBt (22.2 mmol), NMP (22.2 mmol) and EDCI (22.2 mmol) in CH2Cl2 was added thiomorpholine (2.29 g, 22.2 mmol) at 0° C. The reaction mixture was stirred at 0° C. overnight, then washed with 2% aqueous NaOH, water, brine, and dried over Na2SO4. The solvent was removed under vacuum to give (1-Methyl-2-oxo-2-thiomorpholin-4-yl-ethyl)-carbamic acid tert-butyl ester (5.0 g) yield 98%. MS (M+H)=275.

출처