반응 #164865

반응 방정식

Benzaldehyde

benzaldehyde

4-Acetylbenzonitrile

sodium hydroxide

water

→

yellow solid

수율 91.0%

1-(4-Cyanophenyl)-3-phenyl-2-propen-1-one

수율 91.0%

용매

ethanol

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture stirred for 2 hr at room temperature
2. 2
   여과The resulting mixture was filtered
3. 3
   기타recrystallized from ethanol

실험 절차

4-Acetylbenzonitrile (44al, 1.00 g, 6.9 mmol), sodium hydroxide (0.40 g, 10.0 mmol) and water (20 ml) were combined in ethanol (20 ml) and stirred for 15 min at room temperature. Benzaldehyde (1b, 0.70 ml, 6.9 mmol) was added and the mixture stirred for 2 hr at room temperature. The resulting mixture was filtered and recrystallized from ethanol to give 1.46 g (91%) of a yellow solid: mp 120° C. [expected mp 119-120° C.]; 1H NMR: δ 7.34 (m, 3H), 7.62 (m, 2H), 7.80 (m, 4H), 8.06 (d, 2H, J=8.1 Hz); 13C NMR: δ 115.9, 117.9, 121.1, 128.6, 128.8, 129.0, 131.0, 132.4, 134.3, 141.4, 146.4, 188.9.

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