반응 #164679

반응 방정식

Ethyl 4-chloroacetoacetate

2-methyl-2-propanethiol

triethylamine

→

desired product

4-tert-Butylsulfanyl-3-oxo-butyric acid ethyl ester

용매

THF

반응 조건

후처리

1. 1
   workup.ADDITIONSilica gel was added
2. 2
   농축the mixture was concentrated
3. 3
   여과filtered over a plug of silica gel

실험 절차

Ethyl 4-chloroacetoacetate (7.5 mL, 51.9 mmol), 2-methyl-2-propanethiol (5.6 mL, 49.7 mmol), triethylamine (10.8 mL, 77.4 mmol), and catalytic tetrabutylammonium bromide were dissolved in THF (250 mL) and stirred at room temperature overnight. Silica gel was added, and the mixture was concentrated and filtered over a plug of silica gel to obtain the desired product (B-1), which was used without further purification.

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