반응 #164662

반응 방정식

5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

K2CO3

toluene

→

1-(tetrahydro-2H-pyran-2-yl)-5-vinyl-1H-indazole

수율 74.0%

용매

water

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated
2. 2
   추출the residue was extracted with ethyl acetate
3. 3
   세척washed with water
4. 4
   건조The organic layer was dried over anhydrous sodium sulfate
5. 5
   농축concentrated

실험 절차

To a solution of 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (0.5 g, 1.778 mmol) in toluene (10 mL) and water (10 mL) were added K2CO3 (0.492 g, 3.56 mmol), trivinylboroxin pyridine complex (0.514 g, 2.134 mmol), and Tetrakis (0.206 g, 0.178 mmol). The reaction mixture was heated at 110° C. for 4 h. The reaction mixture was concentrated and the residue was extracted with ethyl acetate and washed with water. The organic layer was dried over anhydrous sodium sulfate and concentrated to give 1-(tetrahydro-2H-pyran-2-yl)-5-vinyl-1H-indazole (0.3 g, 74%). LCMS (ES-API), m/z 144 (M-THP).

출처