반응 #164607

반응 방정식

sodium metaperiodate

N-methyl-N—((S)-6-vinyl-1,2,3,4-tetrahydronaphthalen-2-yl)-5-cyclopropylmethoxypyridine-2-carboxamide

2-propanol

water

→

N—((S)-6-Formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-5-cyclopropylmethoxypyridine-2-carboxamide

용매

sodium carbonate

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   건조The organic phase was dried over sodium sulfate
3. 3
   여과filtered
4. 4
   농축concentrated
5. 5
   기타The product was thus obtained with the molecular weight of 364.45 (C22H24N2O3)

실험 절차

A mixture of N-methyl-N—((S)-6-vinyl-1,2,3,4-tetrahydronaphthalen-2-yl)-5-cyclopropylmethoxypyridine-2-carboxamide (1.40 g), 2-propanol (4 ml) and water (2 ml) was admixed with osmium(VIII) oxide (49 mg) and sodium metaperiodate (1.82 g), and the mixture was stirred for 12 hours. The reaction mixture was diluted with saturated sodium carbonate solution and extracted with ethyl acetate. The organic phase was dried over sodium sulfate, filtered and concentrated. The product was thus obtained with the molecular weight of 364.45 (C22H24N2O3); MS (ESI): 365 (M+H+).

출처