반응 #164602

반응 방정식

{(S)-6-[(4-methoxybenzyl)(tetrahydropyran-4-ylmethyl)carbamoyl]-1,2,3,4-tetrahydronaphthalen-2-yl}carbamic acid tert-butyl ester

trifluoroacetic acid

potassium carbonate

→

(S)-6-{[(4-Methoxybenzyl)(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-ylamine

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The organic phase was removed
2. 2
   건조dried over sodium sulfate
3. 3
   농축concentrated
4. 4
   workup.ADDITIONtreated
5. 5
   기타according to method H with lithium aluminum hydride (reaction time 4 hours)
6. 6
   기타The product was thus obtained with the molecular weight of 394.56 (C25H34N2O2)

실험 절차

A mixture of {(S)-6-[(4-methoxybenzyl)(tetrahydropyran-4-ylmethyl)carbamoyl]-1,2,3,4-tetrahydronaphthalen-2-yl}carbamic acid tert-butyl ester (9.90 g) and dichloromethane (30 ml) was admixed cautiously with trifluoroacetic acid (2.2 g). After one hour, the reaction mixture was basified with saturated potassium carbonate solution. The organic phase was removed, dried over sodium sulfate and concentrated. The crude product was taken up in THF (300 ml) and treated according to method H with lithium aluminum hydride (reaction time 4 hours). The product was thus obtained with the molecular weight of 394.56 (C25H34N2O2); MS

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