반응 #164599

반응 방정식

4-cyclohexylbenzoic acid

1-ethyl-3-(3-dimethylamino-propyl)carbodiimide

1-hydroxybenzotriazole

diisopropylethylamine

((S)-6-{[(4-methoxybenzyl)-(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)methylamine

→

4-Cyclohexyl-N—((S)-6-{[(4-methoxybenzyl)(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide

용매

DMF

반응 조건

후처리

1. 1
   기타Volatile fractions were removed after 12 hours
2. 2
   기타The residue was purified by preparative HPLC
3. 3
   기타The product was thus obtained with the molecular weight of 594.84 (C28H38N2O3)

실험 절차

A mixture of 4-cyclohexylbenzoic acid (45 mg), DMF (1 ml), 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide (hydrochloride, 45 mg) and 1-hydroxybenzotriazole (32 mg) was admixed after 5 minutes with diisopropylethylamine (30 mg) and ((S)-6-{[(4-methoxybenzyl)-(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)methylamine (80 mg). Volatile fractions were removed after 12 hours. The residue was purified by preparative HPLC. The product was thus obtained with the molecular weight of 594.84 (C28H38N2O3); MS (ESI) 595 (M+H+).

출처