반응 #164593

반응 방정식

sodium cyanoborohydride

4-cyclopropylmethoxy-N—((S)-6-formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide

THF

C-(tetrahydropyran-4-yl)methylamine

→

4-Cyclopropylmethoxy-N-methyl-N—((S)-6-{[(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)benzamide

용매

acetic acid

반응 조건

후처리

1. 1
   여과The polymer was filtered off with suction
2. 2
   농축the filtrate was concentrated
3. 3
   기타The residue was purified by preparative HPLC
4. 4
   기타The product was thus obtained with the monoisotopic molecular weight of 462.29 (C28H38N2O3)

실험 절차

To a mixture of 4-cyclopropylmethoxy-N—((S)-6-formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide (0.20 g), THF (5 ml), C-(tetrahydropyran-4-yl)methylamine (63 mg) and acetic acid (33 mg) was added polymer-bound sodium cyanoborohydride (0.55 mmol), and the suspension was shaken at room temperature for 12 hours. The polymer was filtered off with suction and the filtrate was concentrated. The residue was purified by preparative HPLC. The product was thus obtained with the monoisotopic molecular weight of 462.29 (C28H38N2O3); MS (ESI): 463.3 (M+H+).

출처