반응 #164519

반응 방정식

morpholine

2-hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

Para Toluenesulfonic Acid

→

2-(morpholin-4-yl)methyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

용매

toluene

반응 조건

후처리

1. 1
   기타stirring for 13 hrs
2. 2
   온도at reflux temperature
3. 3
   workup.DISTILLATIONToluene was distilled under vacuum
4. 4
   기타to get a semi-solid with brick red color

실험 절차

2-hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane (Compound 1.50 gm, 0.18 mole), Para Toluenesulfonic Acid (PTSA, 3.5 gms) was dissolved in toluene (300 ml) at 28° C. To this was added 18.5 gm of morpholine drop wise with continuous stirring, continued the stirring for 13 hrs at reflux temperature. Toluene was distilled under vacuum to get a semi-solid with brick red color. The yield of the product was 90%.

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