반응 #164266

반응 방정식

5-Chloro-2-[5-(4-ethoxycarbonyl-piperidin-1-yl)-2-fluoro-phenyl]-benzoimidazole-1-carboxylic acid tert-butyl ester

→

title compound

수율 138.1%

1-[3-(5-Chloro-1H-benzoimidazol-2-yl)-4-fluoro-phenyl]piperidine-4-carboxylic acid hydrochloride

수율 138.1%

용매

HCl

반응 조건

후처리

1. 1
   기타Solvent was removed under vacuum
2. 2
   여과the solid was filtered
3. 3
   세척washed with diethyl ether
4. 4
   기타dried

실험 절차

Method 10—Step b A mixture of 5-Chloro-2-[5-(4-ethoxycarbonyl-piperidin-1-yl)-2-fluoro-phenyl]-benzoimidazole-1-carboxylic acid tert-butyl ester (0.30 g, 0.60 mmol) in 6N HCl (10 mL) was heated in microwave at 120° C. for 15 minutes, two cycles were needed. Solvent was removed under vacuum, then the solid was filtered and washed with diethyl ether and dried to obtain 0.17 g of the title compound (70%).

출처