반응 #164228

반응 방정식

(R)-quinuclidin-3-yl 2-(4-fluorobenzylamino)-2-phenylacetate

2-bromo-1-phenylethanone

→

title compound

수율 37.0%

(R)-3-[2-(4-fluoro-benzylamino)-2-phenyl-acetoxy]-1-(2-oxo-2-phenyl-ethyl)-1-azonia-bicyclo[2.2.2]octane bromide

수율 37.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   여과The solid is collected by suction filtration
2. 2
   세척washed with Et2O
3. 3
   기타The product is further purified by flash chromatography (DCM/MeOH=95/5 to 92/8)

실험 절차

A mixture of (R)-quinuclidin-3-yl 2-(4-fluorobenzylamino)-2-phenylacetate (C78) (61 mg, 0.17 mmol) and 2-bromo-1-phenylethanone (33.0 mg, 0.17 mmol) in ethyl acetate (3 mL) is stirred at RT overnight. The solid is collected by suction filtration and washed with Et2O. The product is further purified by flash chromatography (DCM/MeOH=95/5 to 92/8) to obtain the title compound as a white solid (35 mg, 37% yield, bromide salt, mixture of diastereoisomers).

출처