반응 #164125

반응 방정식

title compound

[8-(4-methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethylamine

H2SO4

→

4-dimethylamino-4-(4-methoxy-phenyl)-cyclohexanone

용매

ether

반응 조건

후처리

1. 1
   기타The phases were separated
2. 2
   추출extracted three times with ether
3. 3
   세척the combined organic phases were then washed with water
4. 4
   건조dried over Na2SO4
5. 5
   농축concentrated to low volume in a vacuum

실험 절차

The title compound from step 1 (6.80 g, 23 mmol) was dissolved in ether (100 mL), mixed with 5% H2SO4 (100 mL) and the solution vigorously stirred for 2 d at RT. The phases were separated and the ether phase discarded. The aqueous phase was made alkaline with 5N NaOH with ice cooling and extracted three times with ether, the combined organic phases were then washed with water, dried over Na2SO4 and concentrated to low volume in a vacuum.

출처