반응 #164108

반응 방정식

title compound

4-oxo-1-phenyl-cyclohexane carbonitrile

ethylene glycol

water

→

8-phenyl-1,4-dioxa-spiro[4.5]decane-8-carbonitrile

용매

toluol

반응 조건

후처리

1. 1
   온도with reflux
2. 2
   온도the mixture was cooled
3. 3
   세척washed with NaHCO3 solution and saturated NaCl solution
4. 4
   건조dried with Na2SO4
5. 5
   농축concentrated to low volume in a vacuum

실험 절차

The title compound of step 2 (43.3 g, 217 mmol) and ethylene glycol (27.4 g, 435 mmol) were boiled in toluol (430 mL) with the addition of p-toluol sulphonic acid (1.87 g, 10.9 mmol) at a water separator for 3 h with reflux. After the reaction had ended, the mixture was cooled, washed with NaHCO3 solution and saturated NaCl solution, dried with Na2SO4 and concentrated to low volume in a vacuum.

출처