반응 #164104

반응 방정식

ether

ethyl-4-oxocyclohexane carboxylate

ethylene glycol

→

raw product

수율 74.0%

1,4-dioxaspiro[4,5]decane-8-carboxylic acid ethyl ester

수율 74.0%

용매

toluol

반응 조건

후처리

1. 1
   세척washed with water and 5% sodium hydrogencarbonate solution (150 mL each)
2. 2
   건조The organic phase was dried with sodium sulphate
3. 3
   농축concentrated to low volume in a vacuum

실험 절차

A solution of ethyl-4-oxocyclohexane carboxylate (28.9 g, 169 mmol), ethylene glycol (36.7 g, 33.0 mL, 592 mmol) and p-toluol sulphonic acid (380 mg, 2.0 mmol) in toluol (90 mL) was stirred overnight at room temperature. The reaction solution was poured into ether (150 mL) and washed with water and 5% sodium hydrogencarbonate solution (150 mL each). The organic phase was dried with sodium sulphate and concentrated to low volume in a vacuum. Since the raw product (26.8 g) was obtained in pure form, it could be directly converted further.

출처