반응 #1637

반응 방정식

(S)-1-(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol

benzyl bromide

sodium carbonate

→

title compound

(S)-N-Benzyl-1(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol

용매

dimethylformamide

반응 조건

후처리

1. 1
   여과The mixture was filtered
2. 2
   세척the residue was washed with ethyl acetate
3. 3
   세척washed with water and brine
4. 4
   기타dried
5. 5
   기타evaporated
6. 6
   기타Purification of the residue by flash chromatography (silica gel, 50% ethyl acetate in hexane)

실험 절차

A solution of (S)-1-(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol (1.9 g, 4.8 mMol) and benzyl bromide (0.57 ml, 4.8 mMol) in dimethylformamide (10 ml) containing sodium carbonate (770 mg, 7.2 mMol) was stirred at room temperature for 18 hours. The mixture was filtered and the residue was washed with ethyl acetate. The filtrates were combined, washed with water and brine, dried and evaporated. Purification of the residue by flash chromatography (silica gel, 50% ethyl acetate in hexane) gave the title compound.

출처