반응 #163547

반응 방정식

N-ethylbenzene-1,2-diamine

2-oxopropanoic acid

→

1-ethyl-3-methyl-quinoxalin-2(1H)-one

수율 56.7%

용매

methanol

반응 조건

후처리

1. 1
   기타The solvent was removed under vacuum
2. 2
   기타The residue was further purified by silica gel column chromatography

실험 절차

5.4 g (39.6 mM) of N-ethylbenzene-1,2-diamine and 2.76 ml (39.6 mM) of 2-oxopropanoic acid in 200 ml of methanol were refluxed for 8 h. The solvent was removed under vacuum. The residue was further purified by silica gel column chromatography, using dichloromethane, followed by dichloromethane/dimethylketone (95/5) as eluant to give 4.2 g of 1-ethyl-3-methyl-quinoxalin-2(1H)-one as a yellow solid. Yield: 56.7%.

출처