반응 #163545

반응 방정식

sodium carbonate

1-ethyl-1,4-dihydroquinoxaline-2,3-dione

POBr3

→

3-bromo-1-ethyl-quinoxalin-2(1H)-one

수율 53.0%

용매

dichloroethane

반응 조건

후처리

1. 1
   온도The reaction mixture was refluxed
2. 2
   workup.ADDITIONtreated with ice cold
3. 3
   여과The mixture was filtered
4. 4
   추출the filtrate was extracted with dichloromethane
5. 5
   건조dried over anhydrous sodium sulfate
6. 6
   농축concentrated

실험 절차

To 2 g (10.5 mM) of 1-ethyl-1,4-dihydroquinoxaline-2,3-dione in 20 ml of dichloroethane were added dropwise 3.16 g (11.0 mM) of POBr3. The reaction mixture was refluxed under stirring for 2 h and then treated with ice cold and an aqueous sodium carbonate solution. The mixture was filtered and the filtrate was extracted with dichloromethane, dried over anhydrous sodium sulfate and concentrated to give 1.4 g of 3-bromo-1-ethyl-quinoxalin-2(1H)-one as a yellow solid. Yield: 53%.

출처