반응 #163481

반응 방정식

trimethylamine oxide

6-bromo-2,2-dimethylhexanenitrile

→

title compound

2,2-dimethyl-6-oxohexanenitrile

용매

DMSO

반응 조건

후처리

1. 1
   기타the reaction mixture was quenched with water (10 mL)
2. 2
   추출extracted with hexanes (4×10 mL)
3. 3
   세척The combined organic extracts were washed with brine (20 mL)
4. 4
   건조dried (NaSO4)
5. 5
   여과filtered
6. 6
   농축concentrated

실험 절차

To a suspension of trimethylamine oxide (1.5 g, 19.6 mmol, Aldrich) in DMSO (10 mL) was added 6-bromo-2,2-dimethylhexanenitrile (0.84 mL, 4.9 mmol, Aldrich). After stirring at room temperature overnight, the reaction mixture was quenched with water (10 mL) and extracted with hexanes (4×10 mL). The combined organic extracts were washed with brine (20 mL), dried (NaSO4), filtered and concentrated to afford 0.65 g (80% pure) of the title compound. MS (ESI+) m/z 157 (M+NH4)+.

출처