반응 #163315

반응 방정식

4-iodophenol

1-bromo-2-methylpropane

K2CO3

DMF

→

1-Iodo-4-isobutoxybenzene

용매

water

반응 조건

후처리

1. 1
   추출extracted with EtOAc
2. 2
   세척The organic layer is washed with diluted aq. NaOH (2×) and water (2×)
3. 3
   건조dried with MgSO4
4. 4
   기타the solvent is removed in vacuo
5. 5
   기타The crude product is used without further purification

실험 절차

3.0 g (13.64 mmol) 4-iodophenol, 1.6 mL (15.00 mmol) 1-bromo-2-methylpropane and 7.5 g (54.54 mmol) K2CO3 are added to 30 mL DMF and stirred at 80° C. for 4 h. Afterwards the reaction mixture is diluted with water and extracted with EtOAc. The organic layer is washed with diluted aq. NaOH (2×) and water (2×), dried with MgSO4 and the solvent is removed in vacuo. The crude product is used without further purification.

출처