반응 #163281

반응 방정식

5-amino-1-methyl-1H-indole

thiocarbonyl diimidazole

→

5-isothiocyanato-1-methyl-1H-indole

수율 78.3%

용매

ethyl acetate

반응 조건

후처리

1. 1
   온도after cooling
2. 2
   기타the solvent was evaporated
3. 3
   workup.DISSOLUTIONThe crude material was dissolved in dichloromethane (100 mL)
4. 4
   여과filtered through a short plug of silica gel, which
5. 5
   세척was washed with another bolus of dichloromethane (100 mL)
6. 6
   기타The organic eluent was evaporated

실험 절차

A flask was charged with 5-amino-1-methyl-1H-indole (8.8 g; 60 mmol), thiocarbonyl diimidazole (10.7 g; 60 mmol) and ethyl acetate (200 mL). The reaction was heated at 50° C. for five minutes, and after cooling, the solvent was evaporated. The crude material was dissolved in dichloromethane (100 mL) and filtered through a short plug of silica gel, which was washed with another bolus of dichloromethane (100 mL). The organic eluent was evaporated to give 5-isothiocyanato-1-methyl-1H-indole (8.9 g; 47 mmol).

출처