반응 #162880

ord-bb9ecf7bee554097a3121f005ebcafd2

반응 방정식

c1cc(NC2CC3CCC2N3)c2ccncc2c1
Intermediate 29
c1cc(NC2CC3CCC2N3)c2ccncc2c1
N-((1SR,2RS,4RS)-7-azabicyclo[2.2.1]heptan-2-yl)isoquinolin-5-amine
Cc1ccc(C=O)cc1
4-methylbenzaldehyde
→
Cc1ccc(CN2C3CCC2C(Nc2cccc4cnccc24)C3)cc1
title compound
Cc1ccc(CN2C3CCC2C(Nc2cccc4cnccc24)C3)cc1
N-((1SR,2RS,4RS)-7-(4-methylbenzyl)-7-azabicyclo[2.2.1]heptan-2-yl)isoquinolin-5-amine

반응물

c1cc(NC2CC3CCC2N3)c2ccncc2c1
Intermediate 29
c1cc(NC2CC3CCC2N3)c2ccncc2c1
N-((1SR,2RS,4RS)-7-azabicyclo[2.2.1]heptan-2-yl)isoquinolin-5-amine
Cc1ccc(C=O)cc1
4-methylbenzaldehyde

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Reaction of Intermediate 29 with 4-methylbenzaldehyde affords the title compound.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08835457B2uspto-grants-2014_09