반응 #162867

반응 방정식

Compound 8

(2S)-tert-butyl 2-(4-(4′-(2-((3S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-imidazol-4-yl)biphenyl-4-yl)-1H-imidazol-2-yl)octahydro-1H-indole-1-carboxylate

water

→

(2S)-2-(4-(4′-(2-((3S)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-imidazol-4-yl)biphenyl-4-yl)-1H-imidazol-2-yl)octahydro-1H-indole

용매

methanol

반응 조건

후처리

1. 1
   기타Resulting
2. 2
   기타reaction
3. 3
   온도The resulting slurry was cooled to RT
4. 4
   여과Filtration of the slurry
5. 5
   기타afforded a solid
6. 6
   세척washed with 15 ml acetone
7. 7
   기타dried directly
8. 8
   기타used in the next reaction

실험 절차

Compound 8 were taken in 9 ml methanol; 1 ml Conc. HCL and 0.2 ml water was added. Resulting reaction was stirred for 5 h at 50° C. (oil bath temp) completed, after completion of the reaction monitor by HPLC. The resulting slurry was cooled to RT and held with agitation for about 1H. Filtration of the slurry afforded a solid; washed with 15 ml acetone dried directly used in the next reaction.

출처